Iranian Red Crescent Medical Journal

Published by: Kowsar

Zolpidem Dependency and Withdrawal Seizure: A Case Report Study

Seyed Alireza Haji Seyed Javadi 1 , Farid Hajiali 2 and Marjan Nassiri-Asl 3 , *
Authors Information
1 Department of Psychiatry, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
2 Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
3 Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: November 19, 2014, 16 (11); e19926
  • Published Online: November 11, 2014
  • Article Type: Case Report
  • Received: May 8, 2014
  • Revised: September 17, 2014
  • Accepted: October 6, 2014
  • DOI: 10.5812/ircmj.19926

To Cite: Haji Seyed Javadi S A, Hajiali F, Nassiri-Asl M. Zolpidem Dependency and Withdrawal Seizure: A Case Report Study, Iran Red Crescent Med J. 2014 ; 16(11):e19926. doi: 10.5812/ircmj.19926.

Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Chen SC, Chen HC, Liao SC, Tseng MC, Lee MB. Detoxification of high-dose zolpidem using cross-titration with an adequate equivalent dose of diazepam. Gen Hosp Psychiatry. 2012; 34(2): 210 e5-7[DOI][PubMed]
  • 2. Holm KJ, Goa KL. Zolpidem: an update of its pharmacology, therapeutic efficacy and tolerability in the treatment of insomnia. Drugs. 2000; 59(4): 865-89[PubMed]
  • 3. Sakkas P, Psarros C, Masdrakis V, Liappas J, Christodoulou GN. Dependence on zolpidem: a case report. European Psychiatry. 1999; 14(6): 358-9[DOI]
  • 4. Pourshams M, Malakouti SK. Zolpidem abuse and dependency in an elderly patient with major depressive disorder: a case report. Daru. 2014; 22: 54[DOI][PubMed]
  • 5. Krueger TH, Kropp S, Huber TJ. High-dose zolpidem dependence in a patient with chronic facial pain. Ann Pharmacother. 2005; 39(4): 773-4[DOI][PubMed]
  • 6. Wang LJ, Ree SC, Chu CL, Juang YY. Zolpidem dependence and withdrawal seizure--report of two cases. Psychiatr Danub. 2011; 23(1): 76-8[PubMed]
  • 7. Cubala WJ, Landowski J. Seizure following sudden zolpidem withdrawal. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(2): 539-40[DOI][PubMed]
  • 8. Keuroghlian AS, Barry AS, Weiss RD. Circadian dysregulation, zolpidem dependence, and withdrawal seizure in a resident physician performing shift work. Am J Addict. 2012; 21(6): 576-7[DOI][PubMed]
  • 9. Victorri-Vigneau C, Dailly E, Veyrac G, Jolliet P. Evidence of zolpidem abuse and dependence: results of the French Centre for Evaluation and Information on Pharmacodependence (CEIP) network survey. Br J Clin Pharmacol. 2007; 64(2): 198-209[DOI][PubMed]
  • 10. Huang MC, Lin HY, Chen CH. Dependence on zolpidem. Psychiatry Clin Neurosci. 2007; 61(2): 207-8[DOI][PubMed]
  • 11. Salva P, Costa J. Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications. Clin Pharmacokinet. 1995; 29(3): 142-53[DOI][PubMed]
  • 12. McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci. 2000; 3(6): 587-92[DOI][PubMed]
  • 13. Courtet P, Pignay V, Castelnau D, Boulenger JP. [Abuse of and dependence on zolpidem: a report of seven cases]. Encephale. 1999; 25(6): 652-7[PubMed]
  • 14. Feneon D, Villemeyre Plane M, Reynaud M. Addiction au zolpidem: about a case. Alcohol Addict. 2001; 23(4): 519-23
  • 15. Liappas IA, Malitas PN, Dimopoulos NP, Gitsa OE, Liappas AI, Nikolaou Ch K, et al. Zolpidem dependence case series: possible neurobiological mechanisms and clinical management. J Psychopharmacol. 2003; 17(1): 131-5[PubMed]
  • 16. Toner LC, Tsambiras BM, Catalano G, Catalano MC, Cooper DS. Central nervous system side effects associated with zolpidem treatment. Clin Neuropharmacol. 2000; 23(1): 54-8[PubMed]
  • 17. Cubala WJ, Landowski J, Wichowicz HM. Zolpidem abuse, dependence and withdrawal syndrome: sex as susceptibility factor for adverse effects. Br J Clin Pharmacol. 2008; 65(3): 444-5[DOI][PubMed]
  • 18. Vartzopoulos D, Bozikas V, Phocas C, Karavatos A, Kaprinis G. Dependence on zolpidem in high dose. Int Clin Psychopharmacol. 2000; 15(3): 181-2[PubMed]
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