Iranian Red Crescent Medical Journal

Published by: Kowsar

The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus

Nakisa Rasaei 1 , Mesbah Shams 2 , Eskandar Kamali-Sarvestani 3 and Mohammad Ali Nazarinia 4 , *
Authors Information
1 Internal Medicine Ward, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Autoimmune Disease Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: December 01, 2015, 17 (12); e17298
  • Published Online: December 5, 2015
  • Article Type: Research Article
  • Received: February 1, 2014
  • Revised: July 20, 2015
  • Accepted: August 12, 2015
  • DOI: 10.5812/ircmj.17298

To Cite: Rasaei N, Shams M, Kamali-Sarvestani E, Nazarinia M A. The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus, Iran Red Crescent Med J. 2015 ; 17(12):e17298. doi: 10.5812/ircmj.17298.

Copyright © 2015, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Mosca M, Bombardieri S. Disease-specific quality indicators, guidelines, and outcome measures in systemic lupus erythematosus (SLE). Clin Exp Rheumatol. 2007; 25(6 Suppl 47): 107-13[PubMed]
  • 2. Griffiths B, Mosca M, Gordon C. Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol. 2005; 19(5): 685-708[DOI][PubMed]
  • 3. Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P, Moutsopoulos HM. Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases. Ann Rheum Dis. 2004; 63(9): 1159-61[DOI][PubMed]
  • 4. Delamere JP, Scott DL, Felix-Davies DD. Autoimmune thyroiditis. J R Soc Med. 2008; : 102-6
  • 5. Goh KL, Wang F. Thyroid disorders in systemic lupus erythematosus. . Ann Rheum Dis. 1986; 45(7): 579-83
  • 6. Konstadoulakis MM, Kroubouzos G, Tosca A, Piperingos G, Marafelia P, Konstadoulakis M, et al. Thyroid autoantibodies in the subsets of lupus erythematosus: correlation with other autoantibodies and thyroid function. Thyroidology. 1993; 5(1): 1-7[PubMed]
  • 7. Chan AT, Al-Saffar Z, Bucknall RC. Thyroid disease in systemic lupus erythematosus and rheumatoid arthritis. Rheumatology (Oxford). 2001; 40(3): 353-4[PubMed]
  • 8. Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis. 2002; 61(1): 70-2[PubMed]
  • 9. Mader R, Mishail S, Adawi M, Lavi I, Luboshitzky R. Thyroid dysfunction in patients with systemic lupus erythematosus (SLE): relation to disease activity. Clin Rheumatol. 2007; 26(11): 1891-4[DOI][PubMed]
  • 10. Antonelli A, Fallahi P, Mosca M, Ferrari SM, Ruffilli I, Corti A, et al. Prevalence of thyroid dysfunctions in systemic lupus erythematosus. Metabolism. 2010; 59(6): 896-900[DOI][PubMed]
  • 11. Appenzeller S, Pallone AT, Natalin RA, Costallat LT. Prevalence of thyroid dysfunction in systemic lupus erythematosus. J Clin Rheumatol. 2009; 15(3): 117-9[DOI][PubMed]
  • 12. Al-Awadhi AM, Olusi S, Hasan EA, Abdullah A. Frequency of abnormal thyroid function tests in Kuwaiti Arabs with autoimmune diseases. Med Princ Pract. 2008; 17(1): 61-5[DOI][PubMed]
  • 13. Weetman AP, Walport MJ. The association of autoimmune thyroiditis with systemic lupus erythematosus. Br J Rheumatol. 1987; 26(5): 359-61[PubMed]
  • 14. Smith EL, Shmerling RH. The American College of Rheumatology criteria for the classification of systemic lupus erythematosus: strengths, weaknesses, and opportunities for improvement. Lupus. 1999; 8(8): 586-95[PubMed]
  • 15. Hahn BH, Fauci AS, Braunwald Ek DL, Hauser SL, Longo DL, Harrison's Principals of Internal Medicine. 2008; : 2075-83
  • 16. Mills JA. Systemic lupus erythematosus. N Engl J Med. 1994; 330(26): 1871-9[DOI][PubMed]
  • 17. Pisetsky DS. Systemic lupus erythematosus. Med Clin North Am. 1986; 70(2): 337-53
  • 18. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003; 349(16): 1526-33[DOI][PubMed]
  • 19. Lin WY, Chang CL, Fu LS, Lin CH, Lin HK. Systemic lupus erythematosus and thyroid disease: A 10-year study. J Microbiol Immunol Infect. 2014; [DOI][PubMed]
  • 20. Pan XF, Gu JQ, Shan ZY. Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis. PLoS One. 2015; 10(4)[DOI][PubMed]
  • 21. Biro E, Szekanecz Z, Czirjak L, Danko K, Kiss E, Szabo NA, et al. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol. 2006; 25(2): 240-5[DOI][PubMed]
  • 22. Vianna JL, Haga HJ, Asherson RA, Swana G, Hughes GR. A prospective evaluation of antithyroid antibody prevalence in 100 patients with systemic lupus erythematosus. J Rheumatol. 1991; 18(8): 1193-5[PubMed]
  • 23. Kausman D, Isenberg DA. Thyroid autoimmunity in systemic lupus erythematosus: the clinical significance of a fluctuating course. Br J Rheumatol. 1995; 34(4): 361-4[PubMed]
  • 24. Park DJ, Cho CS, Lee SH, Park SH, Kim HY. Thyroid disorders in Korean patients with systemic lupus erythematosus. Scand J Rheumatol. 1995; 24(1): 13-7[PubMed]
  • 25. Yoshida H, Amino N, Yagawa K, Uemura K, Satoh M, Miyai K, et al. Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases. J Clin Endocrinol Metab. 1978; 46(6): 859-62[DOI][PubMed]
  • 26. Groves CJ, Howells RD, Williams S, Darke C, Parkes AB. Primary standardization for the ELISA of serum thyroperoxidase and thyroglobulin antibodies and their prevalence in a normal Welsh population. J Clin Lab Immunol. 1990; 32(3): 147-51[PubMed]
  • 27. Miller FW, Moore GF, Weintraub BD, Steinberg AD. Prevalence of thyroid disease and abnormal thyroid function test results in patients with systemic lupus erythematosus. Arthritis Rheum. 1987; 30(10): 1124-31[PubMed]
  • 28. Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43(1): 55-68[PubMed]
  • 29. Hrycek A, Hrycek E, Kopczynski P, Kopczynska M, Romanowski L, Walawska A. [The thyroid functional tests, antithyroid antibodies and the level of prolactin in treated patients with systemic lupus erythematosus]. Pol Merkur Lekarski. 2010; 29(172): 231-4[PubMed]
  • 30. Kumar K, Kole AK, Karmakar PS, Ghosh A. The spectrum of thyroid disorders in systemic lupus erythematosus. Rheumatol Int. 2012; 32(1): 73-8[DOI][PubMed]
  • 31. Franco J, Amaya-Amaya J, Molano-Gonzalez N, Caro-Moreno J, Rodriguez-Jimenez M, Acosta-Ampudia Y, et al. Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus. Clin Endocrinol (Oxf). 2014; [DOI][PubMed]
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