Iranian Red Crescent Medical Journal

Published by: Kowsar

The Effects of Inhalation Aromatherapy on Anxiety in Patients With Myocardial Infarction: A Randomized Clinical Trial

Zahra Najafi 1 , Mohsen Taghadosi 2 , Khadijeh Sharifi 1 , Alireza Farrokhian 3 and Zahra Tagharrobi 1 , *
Authors Information
1 Department of Health Management, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, IR Iran
2 Department of Medical Surgical Nursing, Faculty of Nursing, Kashan University of Medical Sciences, Kashan, IR Iran
3 Department of Internal Medicine, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: August 5, 2014, 16 (8); e15485
  • Published Online: August 5, 2014
  • Article Type: Research Article
  • Received: October 31, 2013
  • Revised: January 2, 2014
  • Accepted: January 28, 2014
  • DOI: 10.5812/ircmj.15485

To Cite: Najafi Z, Taghadosi M, Sharifi K, Farrokhian A, Tagharrobi Z. The Effects of Inhalation Aromatherapy on Anxiety in Patients With Myocardial Infarction: A Randomized Clinical Trial, Iran Red Crescent Med J. 2014 ; 16(8):e15485. doi: 10.5812/ircmj.15485.

Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech. 2011; 4(4): 469-83[DOI][PubMed]
  • 2. Wang Q. Molecular genetics of coronary artery disease. Curr Opin Cardiol. 2005; 20(3): 182-8[PubMed]
  • 3. Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Harrisons principles of internal medicine. 2012; : 1811
  • 4. Shamsi A, Ebadi A. Risk Factors of Cardiovascular Diseases in Elderly People of Tehran. Iran J Crit Care Nurs. 2010; 3(4): 187-92
  • 5. World Health Report. 2012;
  • 6. Babaei M, Kermanshahi SMK, Alhani F. Influence of discharge planning on anxiety levels in patients with myocardial infarction. Koomesh. 2011; 12(3): 272-8
  • 7. Huffman JC, Smith FA, Blais MA, Beiser ME, Januzzi JL, Fricchione GL. Recognition and treatment of depression and anxiety in patients with acute myocardial infarction. Am J Cardiol. 2006; 98(3): 319-24[DOI][PubMed]
  • 8. Januzzi JL, Jr, Stern TA, Pasternak RC, DeSanctis RW. The influence of anxiety and depression on outcomes of patients with coronary artery disease. Arch Intern Med. 2000; 160(13): 1913-21[PubMed]
  • 9. Afzali SM, Masoudi R, Etemadifar S, Moradi M, Moghaddasi J. The effect of progressive muscle relaxation program (PMR) on anxiety of patients undergoing coronary heart angiography. J Shahrekord Univ Med Sci. 2009; 11(3): 77-84
  • 10. De Jong MJ, Moser DK, An K, Chung ML. Anxiety is not manifested by elevated heart rate and blood pressure in acutely ill cardiac patients. Eur J Cardiovasc Nurs. 2004; 3(3): 247-53[DOI][PubMed]
  • 11. Bassampoor S. The effect of relaxation techniques on anxiety of patients with myocardial infarction. Qazvin Uni Medic Sci J (JQUMS). 2005; 9: 1-2
  • 12. Lane D, Carroll D, Lip GY. Anxiety, depression, and prognosis after myocardial infarction: is there a causal association? J Am Coll Cardiol. 2003; 42(10): 1808-10[PubMed]
  • 13. Martin CR, Lewin RJ, Thompson DR. A confirmatory factor analysis of the Hospital Anxiety and Depression Scale in coronary care patients following acute myocardial infarction. Psychiatry Res. 2003; 120(1): 85-94[PubMed]
  • 14. Huffman JC, Smith FA, Blais MA, Januzzi JL, Fricchione GL. Anxiety, independent of depressive symptoms, is associated with in-hospital cardiac complications after acute myocardial infarction. J Psychosom Res. 2008; 65(6): 557-63[DOI][PubMed]
  • 15. Kloner RA. Natural and unnatural triggers of myocardial infarction. Prog Cardiovasc Dis. 2006; 48(4): 285-300[DOI][PubMed]
  • 16. Lane D, Carroll D, Ring C, Beevers DG, Lip GY. Effects of depression and anxiety on mortality and quality-of-life 4 months after myocardial infarction. J Psychosom Res. 2000; 49(4): 229-38[PubMed]
  • 17. Mirbagher ajorpaz N, Ranjbar N. The influence of the holy quran on maternal anxiety before caesarean section: randomized clinical trial. Qom Univ Med Sci J. 2010; 4(1): 15-9
  • 18. Tel H, Tel H. The effect of individualized education on the transfer anxiety of patients with myocardial infarction and their families. Heart Lung. 2006; 35(2): 101-7[DOI][PubMed]
  • 19. Dunning T. Applying a quality use of medicines framework to using essential oils in nursing practice. Complement Ther Clin Pract. 2005; 11(3): 172-81[DOI][PubMed]
  • 20. Perry R, Terry R, Watson LK, Ernst E. Is lavender an anxiolytic drug? A systematic review of randomised clinical trials. Phytomedicine. 2012; 19(8-9): 825-35[DOI][PubMed]
  • 21. Re L, Barocci S, Sonnino S, Mencarelli A, Vivani C, Paolucci G, et al. Linalool modifies the nicotinic receptor-ion channel kinetics at the mouse neuromuscular junction. Pharmacol Res. 2000; 42(2): 177-82[DOI][PubMed]
  • 22. Kutlu AK, Yılmaz E, Çeçen D. Effects of aroma inhalation on examination anxiety. Teach Learn Nurs. 2008; 3(4): 125-30[DOI]
  • 23. Mirzaei F, Keshtgar S, Kaviani M, Rajaeifard A. The effect of lavender essence smelling during labor on cortisol and serotonin plasma levels and anxiety reduction in nulliparous women. J Kerman Univ Med Sci. 2009; 16(3): 245-54
  • 24. Canaani M, Mazloum S, Emami A, Mokhber N. To survey the effect of aromatherapy on lavender on anxiety levels in patients treated with hemodialysis. Nurse Midwife J. 2010; 10(1suppl2): 63-71
  • 25. Brooker DJ, Snape M, Johnson E, Ward D, Payne M. Single case evaluation of the effects of aromatherapy and massage on disturbed behaviour in severe dementia. Br J Clin Psychol. 1997; 36 ( Pt 2): 287-96[PubMed]
  • 26. Graham PH, Browne L, Cox H, Graham J. Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol. 2003; 21(12): 2372-6[DOI][PubMed]
  • 27. Hashemzadeh A, Mirtaghi GF, Chalabianloo G. The study of effectiveness of relaxation and distraction techniques training in anxiety reduction in cardiac patients. Arak Med Univ J. 2011; 14(3): 97-105
  • 28. An K, De Jong MJ, Riegel BJ, McKinley S, Garvin BJ, Doering LV, et al. A cross-sectional examination of changes in anxiety early after acute myocardial infarction. Heart Lung. 2004; 33(2): 75-82[DOI][PubMed]
  • 29. Sharif F, Shoul A, Janati M, Kojuri J, Zare N. The effect of cardiac rehabilitation on anxiety and depression in patients undergoing cardiac bypass graft surgery in Iran. BMC Cardiovasc Disord. 2012; 12: 40[DOI][PubMed]
  • 30. Itai T, Amayasu H, Kuribayashi M, Kawamura N, Okada M, Momose A, et al. Psychological effects of aromatherapy on chronic hemodialysis patients. Psychiatry Clin Neurosci. 2000; 54(4): 393-7[DOI][PubMed]
  • 31. Lehrner J, Marwinski G, Lehr S, Johren P, Deecke L. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiol Behav. 2005; 86(1-2): 92-5[DOI][PubMed]
  • 32. Muzzarelli L, Force M, Sebold M. Aromatherapy and reducing preprocedural anxiety: A controlled prospective study. Gastroenterol Nurs. 2006; 29(6): 466-71[PubMed]
  • 33. ATARHA M, Vakilian K, Rouzbahani N, Bekhradi R. Effect of perineal massage with lavender essence on episiotomy and laceration. J Babol Univ Med Sci. 2009; 11(4): 25-30
  • 34. Nikfarjam M, Parvin N, Asarzadegan N. The effect of Lavandula angustifolia in the treatment of mild to moderate depression. J Shahrekord Univ Med Sci. 2010; 11(4): 66-73
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