Iranian Red Crescent Medical Journal

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A Glance at Methods for Cleft Palate Repair

Sima Tavakolinejad 1 , 2 , Alireza Ebrahimzadeh Bidskan 1 , Hami Ashraf 3 and Daryoush Hamidi Alamdari 4 , *
Authors Information
1 Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Biochemistry and Nutrition Research Center, Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
4 Biochemistry and Nutrition Research Center, Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: January 1, 1970, 16 (9); e15393
  • Published Online: September 5, 2014
  • Article Type: Review Article
  • Received: October 20, 2013
  • Revised: January 13, 2014
  • Accepted: January 21, 2014
  • DOI: 10.5812/ircmj.15393

To Cite: Tavakolinejad S, Ebrahimzadeh Bidskan A, Ashraf H, Hamidi Alamdari D. A Glance at Methods for Cleft Palate Repair, Iran Red Crescent Med J. 1970 ; 16(9):e15393. doi: 10.5812/ircmj.15393.

Abstract
Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
Acknowledgements
Footnotes
References
  • 1. Bush JO, Jiang R. Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development. Development. 2012; 139(2): 231-43[DOI][PubMed]
  • 2. Farina A, Wyszynski DF, Pezzetti F, Scapoli L, Martinelli M, Carinci F, et al. Classification of oral clefts by affection site and laterality: a genotype-phenotype correlation study. Orthod Craniofac Res. 2002; 5(3): 185-91[PubMed]
  • 3. Khazaei S, Shirani AM, Khazaei M, Najafi F. Incidence of cleft lip and palate in Iran. A meta-analysis. Saudi Med J. 2011; 32(4): 390-3[PubMed]
  • 4. Bianchi F, Calzolari E, Ciulli L, Cordier S, Gualandi F, Pierini A, et al. [Environment and genetics in the etiology of cleft lip and cleft palate with reference to the role of folic acid]. Epidemiol Prev. 2000; 24(1): 21-7[PubMed]
  • 5. Mirfazeli A, Kaviany N, Hosseinpour KR, Golalipour MJ. Incidence of cleft lip and palate in gorgan - northern iran: an epidemiological study. Oman Med J. 2012; 27(6): 461-4[DOI][PubMed]
  • 6. Diehl SR, Erickson RP. Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate. Proc Natl Acad Sci U S A. 1997; 94(10): 5231-6[PubMed]
  • 7. Lau EC, Li ZQ. Protection of mice from teratogen-induced cleft palate by exogenous methionine. Proc Soc Exp Biol Med. 1995; 209(2): 141-5[PubMed]
  • 8. Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, et al. Distinct functions for Bmp signaling in lip and palate fusion in mice. Development. 2005; 132(6): 1453-61[DOI][PubMed]
  • 9. Li L, Lin M, Wang Y, Cserjesi P, Chen Z, Chen Y. BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol. 2011; 349(2): 451-61[DOI][PubMed]
  • 10. Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, et al. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004; 36(10): 1111-6[DOI][PubMed]
  • 11. Juriloff DM, Harris MJ, McMahon AP, Carroll TJ, Lidral AC. Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Res A Clin Mol Teratol. 2006; 76(8): 574-9[DOI][PubMed]
  • 12. Pelton RW, Saxena B, Jones M, Moses HL, Gold LI. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development. J Cell Biol. 1991; 115(4): 1091-105[PubMed]
  • 13. Moreno LM, Mansilla MA, Bullard SA, Cooper ME, Busch TD, Machida J, et al. FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate. Hum Mol Genet. 2009; 18(24): 4879-96[DOI][PubMed]
  • 14. Hallonet M, Hollemann T, Pieler T, Gruss P. Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev. 1999; 13(23): 3106-14[PubMed]
  • 15. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, et al. Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010; 347(1): 109-21[DOI][PubMed]
  • 16. Enomoto H, Nelson CM, Somerville RP, Mielke K, Dixon LJ, Powell K, et al. Cooperation of two ADAMTS metalloproteases in closure of the mouse palate identifies a requirement for versican proteolysis in regulating palatal mesenchyme proliferation. Development. 2010; 137(23): 4029-38[DOI][PubMed]
  • 17. Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y. Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002; 129(17): 4135-46[PubMed]
  • 18. Liu W, Lan Y, Pauws E, Meester-Smoor MA, Stanier P, Zwarthoff EC, et al. The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. Development. 2008; 135(23): 3959-68[DOI][PubMed]
  • 19. Yu L, Gu S, Alappat S, Song Y, Yan M, Zhang X, et al. Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development. 2005; 132(19): 4397-406[DOI][PubMed]
  • 20. Pauws E, Moore GE, Stanier P. A functional haplotype variant in the TBX22 promoter is associated with cleft palate and ankyloglossia. J Med Genet. 2009; 46(8): 555-61[DOI][PubMed]
  • 21. Gao Y, Lan Y, Ovitt CE, Jiang R. Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Dev Biol. 2009; 328(2): 200-9[DOI][PubMed]
  • 22. Snyder-Warwick AK, Perlyn CA, Pan J, Yu K, Zhang L, Ornitz DM. Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proc Natl Acad Sci U S A. 2010; 107(6): 2515-20[DOI][PubMed]
  • 23. Marazita ML, Murray JC, Lidral AC, Arcos-Burgos M, Cooper ME, Goldstein T, et al. Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet. 2004; 75(2): 161-73[DOI][PubMed]
  • 24. Levi B, Brugman S, Wong VW, Grova M, Longaker MT, Wan DC. Palatogenesis: engineering, pathways and pathologies. Organogenesis. 2011; 7(4): 242-54[DOI][PubMed]
  • 25. Moreau JL, Caccamese JF, Coletti DP, Sauk JJ, Fisher JP. Tissue engineering solutions for cleft palates. J Oral Maxillofac Surg. 2007; 65(12): 2503-11[DOI][PubMed]
  • 26. Batra P, Sharma J, Duggal R, Parkash H. Secondary bone grafting in cleft lip and palate with eruption of tooth into the graft: a case report. J Indian Soc Pedod Prev Dent. 2004; 22(1): 8-12[PubMed]
  • 27. Panetta NJ, Gupta DM, Slater BJ, Kwan MD, Liu KJ, Longaker MT. Tissue engineering in cleft palate and other congenital malformations. Pediatr Res. 2008; 63(5): 545-51[DOI][PubMed]
  • 28. Nguyen PD, Lin CD, Allori AC, Schachar JS, Ricci JL, Saadeh PB, et al. Scaffold-based rhBMP-2 therapy in a rat alveolar defect model: implications for human gingivoperiosteoplasty. Plast Reconstr Surg. 2009; 124(6): 1829-39[DOI][PubMed]
  • 29. Meyer S, Molsted K. Long-term outcome of secondary alveolar bone grafting in cleft lip and palate patients: a 10-year follow-up cohort study. J Plast Surg Hand Surg. 2013; 47(6): 503-8[DOI][PubMed]
  • 30. De La Pedraja J, Erbella J, McDonald WS, Thaller S. Approaches to cleft lip and palate repair. J Craniofac Surg. 2000; 11(6): 562-71[PubMed]
  • 31. Waite PD, Waite DE. Bone grafting for the alveolar cleft defect. Semin Orthod. 1996; 2(3): 192-6[PubMed]
  • 32. Amaratunga NA. Occurrence of oronasal fistulas in operated cleft palate patients. J Oral Maxillofac Surg. 1988; 46(10): 834-8[PubMed]
  • 33. Cohen SR, Kalinowski J, LaRossa D, Randall P. Cleft palate fistulas: a multivariate statistical analysis of prevalence, etiology, and surgical management. Plast Reconstr Surg. 1991; 87(6): 1041-7[PubMed]
  • 34. Emory RE, Jr, Clay RP, Bite U, Jackson IT. Fistula formation and repair after palatal closure: an institutional perspective. Plast Reconstr Surg. 1997; 99(6): 1535-8[PubMed]
  • 35. Landheer JA, Breugem CC, van der Molen AB. Fistula incidence and predictors of fistula occurrence after cleft palate repair: two-stage closure versus one-stage closure. Cleft Palate Craniofac J. 2010; 47(6): 623-30[DOI][PubMed]
  • 36. Lu Y, Shi B, Zheng Q, Hu Q, Wang Z. Incidence of palatal fistula after palatoplasty with levator veli palatini retropositioning according to Sommerlad. Br J Oral Maxillofac Surg. 2010; 48(8): 637-40[DOI][PubMed]
  • 37. Mak SY, Wong WH, Or CK, Poon AM. Incidence and cluster occurrence of palatal fistula after furlow palatoplasty by a single surgeon. Ann Plast Surg. 2006; 57(1): 55-9[DOI][PubMed]
  • 38. Ashtiani AK, Fatemi MJ, Pooli AH, Habibi M. Closure of palatal fistula with buccal fat pad flap. Int J Oral Maxillofac Surg. 2011; 40(3): 250-4[DOI][PubMed]
  • 39. Hai HK. Repair of palatal defects with unlined buccal fat pad grafts. Oral Surg Oral Med Oral Pathol. 1988; 65(5): 523-5[PubMed]
  • 40. Hudson JW, Anderson JG, Russell RM, Jr, Anderson N, Chambers K. Use of pedicled fat pad graft as an adjunct in the reconstruction of palatal cleft defects. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 80(1): 24-7[PubMed]
  • 41. Robiony M. The use of silicone sheet to improve buccal fat pad healing in palatal reconstruction. J Plast Reconstr Aesthet Surg. 2010; 63(10)-32[DOI][PubMed]
  • 42. Levi B, Kasten SJ, Buchman SR. Utilization of the buccal fat pad flap for congenital cleft palate repair. Plast Reconstr Surg. 2009; 123(3): 1018-21[DOI][PubMed]
  • 43. Fujimura N, Nagura H, Enomoto S. Grafting of the buccal fat pad into palatal defects. J Craniomaxillofac Surg. 1990; 18(5): 219-22[PubMed]
  • 44. Sharma B, Elisseeff JH. Engineering structurally organized cartilage and bone tissues. Ann Biomed Eng. 2004; 32(1): 148-59[PubMed]
  • 45. Liu X, Ma PX. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng. 2004; 32(3): 477-86[PubMed]
  • 46. Salgado AJ, Coutinho OP, Reis RL. Bone tissue engineering: state of the art and future trends. Macromol Biosci. 2004; 4(8): 743-65[DOI][PubMed]
  • 47. Saranya N, Saravanan S, Moorthi A, Ramyakrishna B, Selvamurugan N. Enhanced osteoblast adhesion on polymeric nano-scaffolds for bone tissue engineering. J Biomed Nanotechnol. 2011; 7(2): 238-44[PubMed]
  • 48. Krishnamoorthy G, Sehgal PK, Mandal AB, Sadulla S. Novel collagen scaffolds prepared by using unnatural D-amino acids assisted EDC/NHS crosslinking. J Biomater Sci Polym Ed. 2013; 24(3): 344-64[DOI][PubMed]
  • 49. Gassling V, Hedderich J, Acil Y, Purcz N, Wiltfang J, Douglas T. Comparison of platelet rich fibrin and collagen as osteoblast-seeded scaffolds for bone tissue engineering applications. Clin Oral Implants Res. 2013; 24(3): 320-8[DOI][PubMed]
  • 50. Kang SW, Kim JS, Park KS, Cha BH, Shim JH, Kim JY, et al. Surface modification with fibrin/hyaluronic acid hydrogel on solid-free form-based scaffolds followed by BMP-2 loading to enhance bone regeneration. Bone. 2011; 48(2): 298-306[DOI][PubMed]
  • 51. Guda T, Walker JA, Pollot BE, Appleford MR, Oh S, Ong JL, et al. In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue regeneration in the rabbit radius. J Mater Sci Mater Med. 2011; 22(3): 647-56[DOI][PubMed]
  • 52. Sellgren KL, Ma T. Perfusion conditioning of hydroxyapatite-chitosan-gelatin scaffolds for bone tissue regeneration from human mesenchymal stem cells. J Tissue Eng Regen Med. 2012; 6(1): 49-59[DOI][PubMed]
  • 53. Wu C, Zhou Y, Fan W, Han P, Chang J, Yuen J, et al. Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials. 2012; 33(7): 2076-85[DOI][PubMed]
  • 54. Johari N, Fathi MH, Golozar MA, Erfani E, Samadikuchaksaraei A. Poly(epsilon-caprolactone)/nano fluoridated hydroxyapatite scaffolds for bone tissue engineering: in vitro degradation and biocompatibility study. J Mater Sci Mater Med. 2012; 23(3): 763-70[DOI][PubMed]
  • 55. Steele MH, Seagle MB. Palatal fistula repair using acellular dermal matrix: the University of Florida experience. Ann Plast Surg. 2006; 56(1): 50-3[PubMed]
  • 56. Clark JM, Saffold SH, Israel JM. Decellularized dermal grafting in cleft palate repair. Arch Facial Plast Surg. 2003; 5(1): 40-4[PubMed]
  • 57. Cole P, Horn TW, Thaller S. The use of decellularized dermal grafting (AlloDerm) in persistent oro-nasal fistulas after tertiary cleft palate repair. J Craniofac Surg. 2006; 17(4): 636-41[PubMed]
  • 58. Gutowska A, Jeong B, Jasionowski M. Injectable gels for tissue engineering. Anat Rec. 2001; 263(4): 342-9[PubMed]
  • 59. Logeart-Avramoglou D, Anagnostou F, Bizios R, Petite H. Engineering bone: challenges and obstacles. J Cell Mol Med. 2005; 9(1): 72-84[PubMed]
  • 60. Kuroda T, Yasuda S, Sato Y. Tumorigenicity studies for human pluripotent stem cell-derived products. Biol Pharm Bull. 2013; 36(2): 189-92[PubMed]
  • 61. Diao Y, Ma Q, Cui F, Zhong Y. Human umbilical cord mesenchymal stem cells: osteogenesis in vivo as seed cells for bone tissue engineering. J Biomed Mater Res A. 2009; 91(1): 123-31[DOI][PubMed]
  • 62. Tobita M, Uysal AC, Ogawa R, Hyakusoku H, Mizuno H. Periodontal tissue regeneration with adipose-derived stem cells. Tissue Eng Part A. 2008; 14(6): 945-53[DOI][PubMed]
  • 63. Conejero JA, Lee JA, Parrett BM, Terry M, Wear-Maggitti K, Grant RT, et al. Repair of palatal bone defects using osteogenically differentiated fat-derived stem cells. Plast Reconstr Surg. 2006; 117(3): 857-63[DOI][PubMed]
  • 64. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992; 13(1): 81-8[PubMed]
  • 65. Goshima J, Goldberg VM, Caplan AI. The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop Relat Res. 1991; (262): 298-311[PubMed]
  • 66. Pourebrahim N, Hashemibeni B, Shahnaseri S, Torabinia N, Mousavi B, Adibi S, et al. A comparison of tissue-engineered bone from adipose-derived stem cell with autogenous bone repair in maxillary alveolar cleft model in dogs. Int J Oral Maxillofac Surg. 2013; 42(5): 562-8[DOI][PubMed]
  • 67. De Kok IJ, Peter SJ, Archambault M, van den Bos C, Kadiyala S, Aukhil I, et al. Investigation of allogeneic mesenchymal stem cell-based alveolar bone formation: preliminary findings. Clin Oral Implants Res. 2003; 14(4): 481-9[PubMed]
  • 68. Kim SH, Kim KH, Seo BM, Koo KT, Kim TI, Seol YJ, et al. Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in a canine peri-implant defect model: a pilot study. J Periodontol. 2009; 80(11): 1815-23[DOI][PubMed]
  • 69. Ou XR, Jian XC, Lin G. [An investigation of restoration of alveolar cleft with engineered bone]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2007; 23(1): 29-31[PubMed]
  • 70. Mylonas D, Vidal MD, De Kok IJ, Moriarity JD, Cooper LF. Investigation of a thermoplastic polymeric carrier for bone tissue engineering using allogeneic mesenchymal stem cells in granular scaffolds. J Prosthodont. 2007; 16(6): 421-30[DOI][PubMed]
  • 71. Behnia H, Khojasteh A, Soleimani M, Tehranchi A, Atashi A. Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: a preliminary report. J Craniomaxillofac Surg. 2012; 40(1): 2-7[DOI][PubMed]
  • 72. Gimbel M, Ashley RK, Sisodia M, Gabbay JS, Wasson KL, Heller J, et al. Repair of alveolar cleft defects: reduced morbidity with bone marrow stem cells in a resorbable matrix. J Craniofac Surg. 2007; 18(4): 895-901[DOI][PubMed]
  • 73. Bueno DF, Kerkis I, Costa AM, Martins MT, Kobayashi GS, Zucconi E, et al. New source of muscle-derived stem cells with potential for alveolar bone reconstruction in cleft lip and/or palate patients. Tissue Eng Part A. 2009; 15(2): 427-35[DOI][PubMed]
  • 74. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. Novel regulators of bone formation: molecular clones and activities. Science. 1988; 242(4885): 1528-34[PubMed]
  • 75. Mayer M, Hollinger J, Ron E, Wozney J. Maxillary alveolar cleft repair in dogs using recombinant human bone morphogenetic protein-2 and a polymer carrier. Plast Reconstr Surg. 1996; 98(2): 247-59[PubMed]
  • 76. Chin M, Ng T, Tom WK, Carstens M. Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg. 2005; 16(5): 778-89[PubMed]
  • 77. Herford AS, Boyne PJ, Rawson R, Williams RP. Bone morphogenetic protein-induced repair of the premaxillary cleft. J Oral Maxillofac Surg. 2007; 65(11): 2136-41[DOI][PubMed]
  • 78. Alonso N, Tanikawa DY, Freitas Rda S, Canan L, Jr, Ozawa TO, Rocha DL. Evaluation of maxillary alveolar reconstruction using a resorbable collagen sponge with recombinant human bone morphogenetic protein-2 in cleft lip and palate patients. Tissue Eng Part C Methods. 2010; 16(5): 1183-9[DOI][PubMed]
  • 79. Francis CS, Mobin SS, Lypka MA, Rommer E, Yen S, Urata MM, et al. rhBMP-2 with a demineralized bone matrix scaffold versus autologous iliac crest bone graft for alveolar cleft reconstruction. Plast Reconstr Surg. 2013; 131(5): 1107-15[DOI][PubMed]
  • 80. Woo EJ. Adverse events reported after the use of recombinant human bone morphogenetic protein 2. J Oral Maxillofac Surg. 2012; 70(4): 765-7[DOI][PubMed]
  • 81. Shirvan MK, Alamdari DH, Mahboub MD, Ghanadi A, Rahimi HR, Seifalian AM. A novel cell therapy for stress urinary incontinence, short-term outcome. Neurourol Urodyn. 2013; 32(4): 377-82[DOI][PubMed]
  • 82. Ravari H, Hamidi-Almadari D, Salimifar M, Bonakdaran S, Parizadeh MR, Koliakos G. Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix. Cytotherapy. 2011; 13(6): 705-11[DOI][PubMed]
  • 83. Shirvan MK, Alamdari DH, Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. J Urol. 2013; 189(6): 2125-9[DOI][PubMed]
  • 84. Oyama T, Nishimoto S, Tsugawa T, Shimizu F. Efficacy of platelet-rich plasma in alveolar bone grafting. J Oral Maxillofac Surg. 2004; 62(5): 555-8[PubMed]
  • 85. Ouyang XY, Qiao J. Effect of platelet-rich plasma in the treatment of periodontal intrabony defects in humans. Chin Med J (Engl). 2006; 119(18): 1511-21[PubMed]
  • 86. Hibi H, Yamada Y, Ueda M, Endo Y. Alveolar cleft osteoplasty using tissue-engineered osteogenic material. Int J Oral Maxillofac Surg. 2006; 35(6): 551-5[DOI][PubMed]
  • 87. Lee C, Nishihara K, Okawachi T, Iwashita Y, Majima HJ, Nakamura N. A quantitative radiological assessment of outcomes of autogenous bone graft combined with platelet-rich plasma in the alveolar cleft. Int J Oral Maxillofac Surg. 2009; 38(2): 117-25[DOI][PubMed]
  • 88. Rullo R, Festa VM, Guida L, Laino G. Bone grafting with platelet-rich plasma in alveolar cleft. Case report. Minerva Stomatol. 2007; 56(1-2): 63-71[PubMed]
  • 89. Luaces-Rey R, Arenaz-Bua J, Lopez-Cedrun-Cembranos JL, Herrero-Patino S, Sironvalle-Soliva S, Iglesias-Candal E, et al. Is PRP useful in alveolar cleft reconstruction? Platelet-rich plasma in secondary alveoloplasty. Med Oral Patol Oral Cir Bucal. 2010; 15(4)-23[PubMed]
  • 90. Marukawa E, Oshina H, Iino G, Morita K, Omura K. Reduction of bone resorption by the application of platelet-rich plasma (PRP) in bone grafting of the alveolar cleft. J Craniomaxillofac Surg. 2011; 39(4): 278-83[DOI][PubMed]
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