Iranian Red Crescent Medical Journal

Published by: Kowsar

The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes

Weiguo Bao 1 , Feng Pan 2 , Ling Chen 1 , Guohai Su 2 , Xiaoyuan Gao 2 , Ying Li 2 , Qiang Sun 1 , Jinhui Sun 1 , Kun He 2 and Hui Song 2 , 3 , *
Authors Information
1 Department of Cardiac Surgery, Second Hospital of Shandong University, Jinan, PR China
2 Department of Cardiology, Jinan Central Hospital of Shandong University, Jinan, PR China
3 School of Public Health, Shandong University, Jinan, PR China
Article information
  • Iranian Red Crescent Medical Journal: April 5, 2014, 16 (4); e14914
  • Published Online: April 5, 2014
  • Article Type: Research Article
  • Received: September 17, 2013
  • Revised: December 18, 2013
  • Accepted: January 28, 2014
  • DOI: 10.5812/ircmj.14914

To Cite: Bao W, Pan F, Chen L, Su G, Gao X, et al. The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes, Iran Red Crescent Med J. 2014 ; 16(4):e14914. doi: 10.5812/ircmj.14914.

Abstract
Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Tarquini R, Lazzeri C, Pala L, Rotella CM, Gensini GF. The diabetic cardiomyopathy. Acta Diabetol. 2011; 48(3): 173-81[DOI][PubMed]
  • 2. Younce CW, Burmeister MA, Ayala JE. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol. 2013; 304(6)-18[DOI][PubMed]
  • 3. Singh AB, Guleria RS, Nizamutdinova IT, Baker KM, Pan J. High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling. J Cell Physiol. 2012; 227(6): 2632-44[DOI][PubMed]
  • 4. Zhou X, Lu X. The role of oxidative stress in high glucose-induced apoptosis in neonatal rat cardiomyocytes. Exp Biol Med (Maywood). 2013; 238(8): 898-902[DOI][PubMed]
  • 5. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999; 96(6): 857-68[PubMed]
  • 6. Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2011; 286(9): 7468-78[DOI][PubMed]
  • 7. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003; 423(6939): 550-5[DOI][PubMed]
  • 8. Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, et al. The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol. 2002; 168(10): 5024-31[PubMed]
  • 9. Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, et al. The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem. 2005; 280(21): 20814-23[DOI][PubMed]
  • 10. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC, et al. The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem. 2004; 279(2): 1513-25[DOI][PubMed]
  • 11. Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N. FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal. 2005; 7(5-6): 752-60[DOI][PubMed]
  • 12. Wang L, Ma W, Markovich R, Chen JW, Wang PH. Regulation of cardiomyocyte apoptotic signaling by insulin-like growth factor I. Circ Res. 1998; 83(5): 516-22[PubMed]
  • 13. Sussman MA, Volkers M, Fischer K, Bailey B, Cottage CT, Din S, et al. Myocardial AKT: the omnipresent nexus. Physiol Rev. 2011; 91(3): 1023-70[DOI][PubMed]
  • 14. Evans-Anderson HJ, Alfieri CM, Yutzey KE. Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res. 2008; 102(6): 686-94[DOI][PubMed]
  • 15. Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A. 2007; 104(51): 20517-22[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments