Iranian Red Crescent Medical Journal

Published by: Kowsar

Nigella sativa Pretreatment in Guinea Pigs Exposed to Cigarette Smoke Modulates In Vitro Tracheal Responsiveness

Rana Keyhanmanesh 1 , 2 , 3 , Hossein Nazemiyeh 4 , Hossein Mazouchian 5 , Mohammad Mahdi Bagheri Asl 5 , Mahdi Karimi Shoar 5 , Mohammad Reza Alipour 3 , * and Mohammad Hossein Boskabady 6
Authors Information
1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Department of Physiology, Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Pharmaceutical Nanotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
5 Student Research Committee, Student Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
6 Departmentof Physiology, Medical School and Pharmacological Research Centre of Medical Plants, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: July 1, 2014, 16 (7); e10421
  • Published Online: July 5, 2014
  • Article Type: Research Article
  • Received: January 26, 2013
  • Revised: December 8, 2013
  • Accepted: May 6, 2014
  • DOI: 10.5812/ircmj.10421

To Cite: Keyhanmanesh R, Nazemiyeh H, Mazouchian H, Bagheri Asl M M, Karimi Shoar M, et al. Nigella sativa Pretreatment in Guinea Pigs Exposed to Cigarette Smoke Modulates In Vitro Tracheal Responsiveness, Iran Red Crescent Med J. 2014 ; 16(7):e10421. doi: 10.5812/ircmj.10421.

Abstract
Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Candela M, Guidotti M, Fabbri A, Brigidi P, Franceschi C, Fiorentini C. Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Crit Rev Microbiol. 2011; 37(1): 1-14[DOI][PubMed]
  • 2. Sukkar MB, Chung KF. Airway smooth muscle in asthma and COPD. 2008; : 201-35[DOI]
  • 3. Currie GP. ABC of COPD. 2011; : 1-6
  • 4. Jrah Harzallah H, Kouidhi B, Flamini G, Bakhrouf A, Mahjoub T. Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and thymoquinone. Food Chem. 2011; 129(4): 1469-74[DOI]
  • 5. Hadjzadeh MA, Khoei A, Hadjzadeh Z, Parizady M. Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats. Urol J. 2007; 4(2): 86-90[PubMed]
  • 6. Kanter M, Coskun O, Kalayci M, Buyukbas S, Cagavi F. Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum Exp Toxicol. 2006; 25(3): 127-33[PubMed]
  • 7. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005; 5(13-14): 1749-70[DOI][PubMed]
  • 8. Keyhanmanesh R, Boskabady MH, Eslamizadeh MJ, Khamneh S, Ebrahimi MA. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs. Planta Med. 2010; 76(3): 218-22[DOI][PubMed]
  • 9. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, et al. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003; 17(10): 1209-14[DOI][PubMed]
  • 10. Boskabady MH, Shiravi N. Inhibitory effect of Nigella Sativa on histamine (H1) receptors of isolated guinea pig tracheal chains. Eur Respir J. 2000; 16(31): 461
  • 11. Boskabady MH, Shirmohammadi B. Effect of Nigella Sativa on isolated guinea pig tracheal chains. Arch Iran Med. 2002; 5: 103-7
  • 12. Boskabady MH, Shirmohammadi B, Jandaghi P, Kiani S. Possible mechanisms For relaxant effect of aqueous and macerate extracts from Nigella sativa on tracheal chains of guinea pig. BMC Clin Pharmacol. 2004; 4(1): 3[DOI]
  • 13. Boskabady MH, Kiani S, Jandaghi P. Stimulatory effect of Nigella sativa on ß2- adronceptors of guinea pig tracheal chains. Med J I R I. 2004; 18: 153-8
  • 14. Boskabady MH, Kiani S, Khoei AR, Aslani MR. Tracheal Responsiveness to Histamine and Histamine (H1) Receptor Blockade by Chlorpheniramine in an Animal Model of COPD. Intern J Pharmacol. 2005; 1(4): 350-6
  • 15. Boskabady MH, Kiani S, Jandaghi P, Ziaei T, Zarei A. Antitussive of Nigella sativa. Pak J Med Sci. 2004; 20: 224-8
  • 16. Boskabady MH, Keyhanmanesh R, Khamneh S, Ebrahimi MA. The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs. Clinics (Sao Paulo). 2011; 66(5): 879-87[PubMed]
  • 17. Keyhanmanesh R, Boskabady MH, Ebrahimi Saadatloo MA, khamnei S. The contribution of water and lipid soluble substances in the relaxant effects of Nigella sativa extract on guinea pig tracheal smooth muscle (in vitro). Ir J Med Sci . 2007; 10(3): 154-61
  • 18. van Antwerpen L, Theron AJ, Myer MS, Richards GA, Wolmarans L, Booysen U, et al. Cigarette smoke-mediated oxidant stress, phagocytes, vitamin C, vitamin E, and tissue injury. Ann N Y Acad Sci. 1993; 686: 53-65[PubMed]
  • 19. Boskabady MH, Keyhanmanesh R, Saadatloo MA. Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s). Indian J Exp Biol. 2008; 46(12): 805-10[PubMed]
  • 20. Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. Euro Res J. 2000; 16(3): 534[DOI]
  • 21. Cavalcante AG, de Bruin PF. The role of oxidative stress in COPD: current concepts and perspectives. J Bras Pneumol. 2009; 35(12): 1227-37[PubMed]
  • 22. Rahman I. Antioxidant therapies in COPD. Int J Chron Obstruct Pulmon Dis. 2006; 1(1): 15-29[PubMed]
  • 23. Corradi M, Rubinstein I, Andreoli R, Manini P, Caglieri A, Poli D, et al. Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2003; 167(10): 1380-6[DOI][PubMed]
  • 24. Tug T, Karatas F, Terzi SM. Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease. Clin Invest Med. 2004; 27(3): 123-8[PubMed]
  • 25. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995; 61(1): 33-6[DOI][PubMed]
  • 26. Kelly FJ. Use of antioxidants in the prevention and treatment of disease. J Int Fed Clin Chem. 1998; 10(1): 21-3[PubMed]
  • 27. Mayne ST. Antioxidant nutrients and chronic disease: use of biomarkers of exposure and oxidative stress status in epidemiologic research. J Nutr. 2003; 133 Suppl 3: 933S-40S[PubMed]
  • 28. Tak PP, Zvaifler NJ, Green DR, Firestein GS. Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases. Immunol Today. 2000; 21(2): 78-82[DOI]
  • 29. Goodyear-Bruch C, Pierce JD. Oxidative stress in critically ill patients. Am J Crit Care. 2002; 11(6): 543-51[PubMed]
  • 30. Stawarz J. Vitamin C May Aid In COPD/Pneumonia Prognosis. Chest. 2006; 130(4): 184
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