Iranian Red Crescent Medical Journal

Published by: Kowsar

Mean Platelet Volume and Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis

Ceren Sen Tanrikulu 1 , Yusuf Tanrikulu 2 , * , Mehmet Zafer Sabuncuoglu 3 , Mehmet Akif Karamercan 4 , Nezih Akkapulu 5 and Figen Coskun 6
Authors Information
1 Department of Emergency Medicine, Ministry of Health, Erzurum Area Training and Research Hospital, Erzurum, Turkey
2 Department of General Surgery, Ministry of Health, Erzurum Area Training and Research Hospital, Erzurum, Turkey
3 Department of General Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey
4 Department of Emergency Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey
5 Department of General Surgery, Ministry of Health, Mus State Hospital, Mus, Turkey
6 Department of Chair of Emergency Medicine, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey
Article information
  • Iranian Red Crescent Medical Journal: May 5, 2014, 16 (5); e10211
  • Published Online: May 5, 2014
  • Article Type: Research Article
  • Received: January 9, 2013
  • Revised: November 22, 2013
  • Accepted: December 30, 2013
  • DOI: 10.5812/ircmj.10211

To Cite: Sen Tanrikulu C, Tanrikulu Y, Zafer Sabuncuoglu M, Akif Karamercan M, Akkapulu N, et al. Mean Platelet Volume and Red Cell Distribution Width as a Diagnostic Marker in Acute Appendicitis, Iran Red Crescent Med J. 2014 ; 16(5):e10211. doi: 10.5812/ircmj.10211.

Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Bergeron E, Richer B, Gharib R, Giard A. Appendicitis is a place for clinical judgement. Am J Surg. 1999; 177(6): 460-2[PubMed]
  • 2. Adesunkanmi AR, Ogunrombi O. Unusual causes of acute abdomen in a Nigerian hospital. West Afr J Med. 2003; 22(3): 264-6[PubMed]
  • 3. Korner H, Sondenaa K, Soreide JA, Andersen E, Nysted A, Lende TH, et al. Incidence of acute nonperforated and perforated appendicitis: age-specific and sex-specific analysis. World J Surg. 1997; 21(3): 313-7[PubMed]
  • 4. Graff L, Russell J, Seashore J, Tate J, Elwell A, Prete M, et al. False-negative and false-positive errors in abdominal pain evaluation: failure to diagnose acute appendicitis and unnecessary surgery. Acad Emerg Med. 2000; 7(11): 1244-55[PubMed]
  • 5. Korner H, Soreide JA, Pedersen EJ, Bru T, Sondenaa K, Vatten L. Stability in incidence of acute appendicitis. A population-based longitudinal study. Dig Surg. 2001; 18(1): 61-6[PubMed]
  • 6. Sack U, Biereder B, Elouahidi T, Bauer K, Keller T, Trobs RB. Diagnostic value of blood inflammatory markers for detection of acute appendicitis in children. BMC Surg. 2006; 6: 15[DOI][PubMed]
  • 7. Torbati SS, Guss DA. Impact of helical computed tomography on the outcomes of emergency department patients with suspected appendicitis. Acad Emerg Med. 2003; 10(8): 823-9[PubMed]
  • 8. Orr RK, Porter D, Hartman D. Ultrasonography to evaluate adults for appendicitis: decision making based on meta-analysis and probabilistic reasoning. Acad Emerg Med. 1995; 2(7): 644-50[PubMed]
  • 9. Coskun K, Mentes O, Atak A, Aral A, Eryilmaz M, Onguru O, et al. Is neopterin a diagnostic marker of acute appendicitis? Ulus Travma Acil Cerrahi Derg. 2012; 18(1): 1-4[DOI][PubMed]
  • 10. Dixon LR. The complete blood count: physiologic basis and clinical usage. J Perinat Neonatal Nurs. 1997; 11(3): 1-18[PubMed]
  • 11. Threatte GA. Usefulness of the mean platelet volume. Clin Lab Med. 1993; 13(4): 937-50[PubMed]
  • 12. Yuksel O, Helvaci K, Basar O, Koklu S, Caner S, Helvaci N, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20(4): 277-81[DOI][PubMed]
  • 13. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008; 75(3): 291-4[DOI][PubMed]
  • 14. Albayrak Y, Albayrak A, Albayrak F, Yildirim R, Aylu B, Uyanik A, et al. Mean platelet volume: a new predictor in confirming acute appendicitis diagnosis. Clin Appl Thromb Hemost. 2011; 17(4): 362-6[DOI][PubMed]
  • 15. Bilici S, Sekmenli T, Goksu M, Melek M, Avci V. Mean platelet volume in diagnosis of acute appendicitis in children. Afr Health Sci. 2011; 11(3): 427-32[PubMed]
  • 16. Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M, et al. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation. 2008; 117(2): 163-8[DOI][PubMed]
  • 17. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005; 352(10): 1011-23[DOI][PubMed]
  • 18. Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med. 2009; 133(4): 628-32[DOI][PubMed]
  • 19. Bansal R, Gupta HL, Goel A, Yadav M. Association of increased platelet volume in patients of chronic obstructive pulmonary disease: Clinical implications. J Indian Acad Clin Med. 2002; 3(2): 169-72
  • 20. Danese S, Motte Cd Cde L, Fiocchi C. Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications. Am J Gastroenterol. 2004; 99(5): 938-45[DOI][PubMed]
  • 21. Makay B, Turkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28(8): 975-8[DOI][PubMed]
  • 22. Yang HR, Wang YC, Chung PK, Chen WK, Jeng LB, Chen RJ. Laboratory tests in patients with acute appendicitis. ANZ J Surg. 2006; 76(1-2): 71-4[DOI][PubMed]
  • 23. Wang LT, Prentiss KA, Simon JZ, Doody DP, Ryan DP. The use of white blood cell count and left shift in the diagnosis of appendicitis in children. Pediatr Emerg Care. 2007; 23(2): 69-76[DOI][PubMed]
  • 24. Cakal B, Akoz AG, Ustundag Y, Yalinkilic M, Ulker A, Ankarali H. Red cell distribution width for assessment of activity of inflammatory bowel disease. Dig Dis Sci. 2009; 54(4): 842-7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments