Iranian Red Crescent Medical Journal

Published by: Kowsar

Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo

Alireza Ghorbanibirgani 1 , * , Ali Khalili 1 and Darioush Rokhafrooz 2
Authors Information
1 Faculty Member of Nursing, Department of Nursing and Midwifery, Gachsaran Branch, Islamic Azad University, Gachsaran, IR Iran
2 Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: June 5, 2014, 16 (6); e4515
  • Published Online: June 5, 2014
  • Article Type: Research Article
  • Received: February 16, 2012
  • Revised: February 18, 2014
  • Accepted: April 28, 2014
  • DOI: 10.5812/ircmj.4515

To Cite: Ghorbanibirgani A, Khalili A, Rokhafrooz D. Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo, Iran Red Crescent Med J. 2014 ; 16(6):e4515. doi: 10.5812/ircmj.4515.

Copyright © 2014, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Burns T, Breathnach S, Cox N, Griffiths C. Rook's Textbook of Dermatology. 2010; : 164-6
  • 2. James WD, Elston DM, Berger TG, Andrews GC. . Andrews' diseases of the skin: Clinical dermatology. 2011; : 115-6
  • 3. Bolognia JL, Jorizzo JL, Rapini R. Dermatology. 2008; : 214
  • 4. Yaghoobi R, Omidian M, Bagherani N. Vitiligo: a review of the published work. J Dermatol. 2011; 38(5): 419-31[PubMed]
  • 5. Ghorbani Birgani A, Masoodi R. Epidemiological study of vitiligo on referred patients from Imam Khomeini Hospital, Ahvaz, Iran, 2009-2012. Jundishapur J Chronic Disease Care. 2013; 2(3): 57-62
  • 6. Szczurko O, Shear N, Taddio A, Boon H. Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trial. BMC Complement Altern Med. 2011; 11: 21[DOI][PubMed]
  • 7. Szczurko O, Boon HS. A systematic review of natural health product treatment for vitiligo. BMC Dermatol. 2008; 8: 2[DOI][PubMed]
  • 8. Ali SA, Meitei KV. Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores. J Pharm Pharmacol. 2011; 63(5): 741-6[DOI][PubMed]
  • 9. Sarkhail P, Esmaily H, Baghaei A, Shafiee A, Abdollahi M, Khademi Y, et al. Burn healing potential of Nigella sativa seed oil in rats. Int J Pharmaceutical Sci Res. 2011; 2(1): 34-40
  • 10. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003; 17(4): 299-305[DOI][PubMed]
  • 11. Vinod KR, Santhosha D, Anbazhagan S. Formulation and Evaluation of Piperine Creama New Herbal Dimensional Approach for Vitiligo Patioents. Int J Pharm and Pharm Sci. 2011; 3(2): 29-33
  • 12. Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Cancer. 1991; 16(1): 67-72[DOI][PubMed]
  • 13. Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD, Panikkar KR. Antitumour principles from Nigella sativa seeds. Cancer Lett. 1992; 63(1): 41-6[PubMed]
  • 14. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res. 1998; 18(3A): 1527-32[PubMed]
  • 15. Nagi MN, Mansour MA. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res. 2000; 41(3): 283-9[DOI][PubMed]
  • 16. Alemi M, Sabouni F, Sanjarian F, Haghbeen K, Ansari S. Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content. AAPS PharmSciTech. 2013; 14(1): 160-7[DOI][PubMed]
  • 17. Ghannadi A, Hajhashemi V, Jafarabadi H. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food. 2005; 8(4): 488-93[DOI][PubMed]
  • 18. Hosseini M, Zakeri S, Khoshdast S, Yousefian FT, Rastegar M, Vafaee F, et al. The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats. J Pharm Bioallied Sci. 2012; 4(3): 219-25[DOI][PubMed]
  • 19. Randhawa MA, Alghamdi MS. Anticancer activity of Nigella sativa (black seed) - a review. Am J Chin Med. 2011; 39(6): 1075-91[DOI][PubMed]
  • 20. Hadjzadeh MA, Khoei A, Hadjzadeh Z, Parizady M. Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats. Urol J. 2007; 4(2): 86-90[PubMed]
  • 21. Yildiz F, Coban S, Terzi A, Savas M, Bitiren M, Celik H, et al. Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys. Ren Fail. 2010; 32(1): 126-31[DOI][PubMed]
  • 22. Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J Altern Complement Med. 2009; 15(6): 639-44[DOI][PubMed]
  • 23. Leong XF, Rais Mustafa M, Jaarin K. Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension. Evid Based Complement Alternat Med. 2013; 2013: 120732[DOI][PubMed]
  • 24. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008; 22(4): 447-52[DOI][PubMed]
  • 25. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012; 26(8): 1246-8[DOI][PubMed]
  • 26. Keyhanmanesh R, Bagban H, Nazemiyeh H, Mirzaei Bavil F, Alipour MR, Ahmady M. The Relaxant Effects of Different Methanolic Fractions of Nigella sativa on Guinea Pig Tracheal Chains. Iran J Basic Med Sci. 2013; 16(2): 123-8[PubMed]
  • 27. Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2010; 54(4): 344-54[PubMed]
  • 28. Boskabady MH, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad MR. Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs. J Zhejiang Univ Sci B. 2011; 12(3): 201-9[DOI][PubMed]
  • 29. Isik H, Cevikbas A, Gurer US, Kiran B, Uresin Y, Rayaman P, et al. Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients. Med Princ Pract. 2010; 19(3): 206-11[DOI][PubMed]
  • 30. Boskabady MH, Mohsenpoor N, Takaloo L. Antiasthmatic effect of Nigella sativa in airways of asthmatic patients. Phytomedicine. 2010; 17(10): 707-13[DOI][PubMed]
  • 31. Boskabady MH, Javan H, Sajady M, Rakhshandeh H. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fundam Clin Pharmacol. 2007; 21(5): 559-66[DOI][PubMed]
  • 32. Seif AA. Nigella Sativa reverses osteoporosis in ovariectomized rats. BMC Complement Altern Med. 2014; 14: 22[DOI][PubMed]
  • 33. Terkelsen LH, Eskild-Jensen A, Kjeldsen H, Barker JH, Hjortdal VE. Topical application of cod liver oil ointment accelerates wound healing: an experimental study in wounds in the ears of hairless mice. Scand J Plast Reconstr Surg Hand Surg. 2000; 34(1): 15-20[PubMed]
  • 34. Wolters M. Diet and psoriasis: experimental data and clinical evidence. Br J Dermatol. 2005; 153(4): 706-14[DOI][PubMed]
  • 35. Damsgaard CT, Lauritzen L, Kjaer TM, Holm PM, Fruekilde MB, Michaelsen KF, et al. Fish oil supplementation modulates immune function in healthy infants. J Nutr. 2007; 137(4): 1031-6[PubMed]
  • 36. Weitz D, Weintraub H, Fisher E, Schwartzbard AZ. Fish oil for the treatment of cardiovascular disease. Cardiol Rev. 2010; 18(5): 258-63[DOI][PubMed]
  • 37. Ries A, Trottenberg P, Elsner F, Stiel S, Haugen D, Kaasa S, et al. A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project. Palliat Med. 2012; 26(4): 294-304[DOI][PubMed]
  • 38. Arshad A, Al-Leswas D, Stephenson J, Metcalfe M, Dennison A. Potential applications of fish oils rich in n-3 fatty acids in the palliative treatment of advanced pancreatic cancer. Br J Nutr. 2011; 106(6): 795-800[DOI][PubMed]
  • 39. Jans LA, Giltay EJ, Van der Does AJ. The efficacy of n-3 fatty acids DHA and EPA (fish oil) for perinatal depression. Br J Nutr. 2010; 104(11): 1577-85[DOI][PubMed]
  • 40. Shahian Madar R, Ghaderi F. Comparison of acid salisylic 2% and betamethasone with topical fish oil in recovery of psoriasis signs. J Qazvin Univ Med Sci. 2004; 8(2): 3-7
  • 41. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr. 2002; 21(6): 495-505[PubMed]
  • 42. Hamzavi I, Jain H, McLean D, Shapiro J, Zeng H, Lui H. Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Arch Dermatol. 2004; 140(6): 677-83[DOI][PubMed]
  • 43. Taieb A, Picardo M, Vetf Members. The definition and assessment of vitiligo: a consensus report of the Vitiligo European Task Force. Pigment Cell Res. 2007; 20(1): 27-35[DOI][PubMed]
  • 44. Bhor U, Pande S. Scoring systems in dermatology. Indian J Dermatol Venereol Leprol. 2006; 72(4): 315-21[PubMed]
  • 45. Kawakami T, Hashimoto T. Disease severity indexes and treatment evaluation criteria in vitiligo. Dermatol Res Pract. 2011; 2011: 750342[DOI][PubMed]
  • 46. Abdel-Moneim A, Morsy BM, Mahmoud AM, Abo-Seif MA, Zanaty MI. Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt. Experimental Clin Sci International online J. 2013; 12: 943-55
  • 47. Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol. 2013; 19(16): 2529-36[DOI][PubMed]
  • 48. Kaimal S, Thappa DM. Diet in dermatology: revisited. Indian J Dermatol Venereol Leprol. 2010; 76(2): 103-15[DOI][PubMed]
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