Iranian Red Crescent Medical Journal

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Identification of Dysregulated Pathways Associated with Ankylosing Spondylitis Using Pathway Interaction Network

Zhi-Hua Wang 1 , Dong Xiang 1 , Jun-Jie Dong 2 , Shao-Xuan He 1 , Li-Min Guo 1 , Jia Lv 1 , Wei Wei 1 , Nan-Nan Kou 1 and Jun Shu 3 , *
Authors Information
1 Department of Traumatology, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650011, Yunnan Province, China
2 Department of Orthopedics, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
3 Department of Orthopedics, The Second Affiliated Hospital of Kunming Medical University, Kunming, 650011, Yunnan Province, China
Article information
  • Iranian Red Crescent Medical Journal: October 2017, 19 (10); e14172
  • Published Online: June 4, 2017
  • Article Type: Research Article
  • Received: November 10, 2016
  • Revised: February 20, 2017
  • Accepted: March 25, 2017
  • DOI: 10.5812/ircmj.14172

To Cite: Wang Z, Xiang D, Dong J, He S, Guo L, et al. Identification of Dysregulated Pathways Associated with Ankylosing Spondylitis Using Pathway Interaction Network, Iran Red Crescent Med J. 2017 ; 19(10):e14172. doi: 10.5812/ircmj.14172.

Copyright © 2017, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Fellow JCW, Liu C. Sulfasalazine for ankylosing spondylitis. Cochrane Database Systematic Reviews. 2014; 11(2)
  • 2. Bleil J, Maier R, Hempfing A, Schlichting U, Appel H, Sieper J, et al. Histomorphologic and histomorphometric characteristics of zygapophyseal joint remodeling in ankylosing spondylitis. Arthritis Rheumatol. 2014; 66(7): 1745-54[DOI][PubMed]
  • 3. Mark S, Helen D, Karl G. Comment on: 'Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: results from the Danish nationwide DANBIO registry' by S? Cerebrovascular Diseases. 2015; 73(7): 44
  • 4. Jordan F, Nguyen TP, Liu WC. Studying protein-protein interaction networks: a systems view on diseases. Brief Funct Genomics. 2012; 11(6): 497-504[DOI][PubMed]
  • 5. Brown MA, Kenna T, Wordsworth BP. Genetics of ankylosing spondylitis--insights into pathogenesis. Nat Rev Rheumatol. 2016; 12(2): 81-91[DOI][PubMed]
  • 6. Colbert RA, Tran TM, Layh-Schmitt G. HLA-B27 misfolding and ankylosing spondylitis. Mol Immunol. 2014; 57(1): 44-51[DOI][PubMed]
  • 7. Lin TT, Lu J, Qi CY, Yuan L, Li XL, Xia LP, et al. Elevated serum level of IL-27 and VEGF in patients with ankylosing spondylitis and associate with disease activity. Clin Exp Med. 2015; 15(2): 227-31[DOI][PubMed]
  • 8. Vinayagam A, Zirin J, Roesel C, Hu Y, Yilmazel B, Samsonova AA, et al. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 2014; 11(1): 94-9[DOI][PubMed]
  • 9. Jin D, Lee H. A computational approach to identifying gene-microRNA modules in cancer. PLoS Comput Biol. 2015; 11(1)[DOI][PubMed]
  • 10. Glazko GV, Emmert-Streib F. Unite and conquer: univariate and multivariate approaches for finding differentially expressed gene sets. Bioinformatics. 2009; 25(18): 2348-54[DOI][PubMed]
  • 11. Corr M. Wnt signaling in ankylosing spondylitis. Clin Rheumatol. 2014; 33(6): 759-62[DOI][PubMed]
  • 12. Liu KQ, Liu ZP, Hao JK, Chen L, Zhao XM. Identifying dysregulated pathways in cancers from pathway interaction networks. BMC Bioinformatics. 2012; 13: 126[DOI][PubMed]
  • 13. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 2003; 31(4)[PubMed]
  • 14. Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003; 19(2): 185-93[PubMed]
  • 15. Bolstad BA. Built-in processing methods. 2013;
  • 16. Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, Minguez P, et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 2011; 39-8[DOI][PubMed]
  • 17. Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015; 43-52[DOI][PubMed]
  • 18. Croft D, Mundo AF, Haw R, Milacic M, Weiser J, Wu G, et al. The Reactome pathway knowledgebase. Nucleic Acids Res. 2014; 42-7[DOI][PubMed]
  • 19. Ahn T, Lee E, Huh N, Park T. Personalized identification of altered pathways in cancer using accumulated normal tissue data. Bioinformatics. 2014; 30(17)-9[DOI][PubMed]
  • 20. Bro R, Smilde AK. Principal component analysis. Analytical Method. 2014; 6(9): 2812-31
  • 21. Haynes W. Student's t-test. Encyclopedia of systems biology. 2013; : 2023-5
  • 22. Nahler G. Pearson correlation coefficient. 2009; : 132
  • 23. Nibbe RK, Chowdhury SA, Koyuturk M, Ewing R, Chance MR. Protein-protein interaction networks and subnetworks in the biology of disease. Wiley Interdiscip Rev Syst Biol Med. 2011; 3(3): 357-67[DOI][PubMed]
  • 24. Chang CC, Lin CJ. Libsvm. ACM Transaction Intel System Technol. 2011; 2(3): 1-27[DOI]
  • 25. Huang J, Ling CX. Using AUC and accuracy in evaluating learning algorithms. Knowledge Data Engin. 2005; 17(3): 299-310
  • 26. Rojatkar DV, Chinchkhede KD, Sarate GG. Handwritten Devnagari consonants recognition using MLPNN with five fold cross validation. 2013;
  • 27. Medenbach J, Seiler M, Hentze MW. Translational control via protein-regulated upstream open reading frames. Cell. 2011; 145(6): 902-13[DOI][PubMed]
  • 28. Hadziselimovic N, Vukojevic V, Peter F, Milnik A, Fastenrath M, Fenyves BG, et al. Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex. Cell. 2014; 156(6): 1153-66[DOI][PubMed]
  • 29. Mazumder B, Seshadri V, Fox PL. Translational control by the 3'-UTR: the ends specify the means. Trends Biochem Sci. 2003; 28(2): 91-8[DOI][PubMed]
  • 30. Jia J, Yao P, Arif A, Fox PL. Regulation and dysregulation of 3'UTR-mediated translational control. Curr Opin Genet Dev. 2013; 23(1): 29-34[DOI][PubMed]
  • 31. Mrugasiewicz M. Monte carlo study of phonon transport in solid thin films including dispersion and polarization. J Heat Transfer. 2001; 123(4): 749-59
  • 32. Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell. 2003; 115(2): 187-98[PubMed]
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