Document Type : Research articles
Authors
- Atefe Asgharian 1
- Vida Mohammadi 2
- Zahra Gholi 2
- Ahmad Esmaillzade 3
- Awat Feizi 4
- Gholamreza Askari 2
1 Treatment Affair, Shahrekord University of Medical Sciences, Shahrekord, IR Iran
2 Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IR Iran
3 Department of Community Nutrition, School of Nutrition Sciences & Dietetics, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, IR Iran
Abstract
Background: Regarding the growing prevalence of non-alcoholic fatty liver disease, concentrating on various strategies for its prevention and management seems necessary.
Objectives: This study aimed to assess the effects of synbiotic administration on body composition and lipid profile in patients with NAFLD.
Methods: Eighty patients with NAFLD participated in this randomized, double-blind, placebo-controlled clinical trial (from March to July 2014) in Iran. Based on AST and ALT as main variables of the study, 34 patients were required in each group (power 80% and α = 5%). Considering a 20% sample loss, 80 patients were enrolled. Synbiotic supplement in form of a 500 mg capsule (containing 7 species of probiotic bacteria and Fructooligosaccharides) was administrated to patients in the intervention group and those in the placebo group received 1 placebo capsule daily for 8 weeks. At the baseline and the end of the study, body composition and lipid profile were evaluated.
Results: A significant reduction was observed in weight (P = 0.001), body fat (P = 0.02), and total cholesterol (P = 0.04) within the synbiotic group. On the other hand, WC (P = 0.02), total cholesterol, and LDL-c (P = 0.04 and P = 0.001, respectively) were significantly increased in the placebo group. TG, HDL-c, and FBG levels remained statistically unchanged in both groups. Significance betweengroup differences were seen in total cholesterol (P = 0.01), LDL (P = 0.01), weight, WC, and body fat after adjustment for energy intake (P = 0.05).
Conclusions: Synbiotic supplementation may improve lipid profile and body composition in patients with NAFLD and might be useful in prevention of the disease progression.
Keywords
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