Document Type : Research articles

Authors

• Tahmineh Tavakoli ¹
• Toba Kazemi ¹
• Homa Mollaei ²
• Fatemeh Salmani ³
• Samira Saghafi ⁴
• Ensiah Sadat Mousavi ⁴
• Mahyar Mohamadifard ¹
• Gholamreza Sharifzadeh ⁵

¹ Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

² Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

³ Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran

⁴ Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

⁵ Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent liver diseases worldwide. There are several com- mon risk factors between NAFLD and coronary artery disease (CAD). Objectives: This study aims to evaluate the relationship between the prevalence of Non-alcoholic fatty liver disease (NAFLD) with
severity of Coronary Artery Disease (CAD) in patients undergoing coronary artery angiography. Methods: This study was a cross-sectional, descriptive-analysis research that included 514 patients who underwent angiography.
The severity of CAD was assessed by the number of vessels involved (vessel score: vd). An ultrasound was performed for all the patients also, intensity of fatty liver involvement was graded from zero (absence of steatosis) to three (severe steatosis). Results: Ultrasonographic examination proven NAFLD in 59.1% of patients with different grades. Patients with NAFLD had signifi- cantly higher body mass index (P < 0.001), waist circumference (P = 0.03), and age (P < 0.001). In addition, there were significant differences between ALT and AST within the normal group and NAFLD patients (P < 0.001). Moreover, coronary angiographic data indicated that the presence of NAFLD significantly correlated with the CAD severity score as so: 64% of people with 2vd and 60.5% of people with three-vessle lisense had fatty liver that was statistically significant (df = 4; P = 0.014). Conclusions: This study showed a high prevalence of NAFLD in patients with documented CAD. It is extremely important since knowing risk factors, designing screening programs, and early treatment of fatty liver could lead to reducing the risk of cardiovas- cular diseases.

Keywords

• Angiography
• Coronary Artery Disease
• Non-Alcoholic Fatty Liver Disease
• Ultrasound