Document Type : Research articles
Authors
- Farsad Imani 1
- Azadeh Ahmadi Tabatabaei 2
- Reza Shariat Moharari 3
- Farhad Etezadi 3
- Pejman Pourfakhr 1
- Mohammad Reza Khajavi 4
1 Assistant Professor of Anesthesiology, Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, IR Iran
2 Resident of Anesthesiology, Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, IR Iran
3 Associate Professor of Anesthesiology, Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, IR Iran
4 Professors of Anesthesiology, Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, IR Iran
Abstract
Background: Aminophylline expedites the recovery from total intravenous and inhalation anesthesia.
Objectives: The aim of this study was to evaluate low and high doses of aminophylline on extubation time, time to discharge from recovery, and the bispectral index score (BIS) in patients who received isoflurane anesthesia.
Patients and Methods: After ethical approval and informed consent were obtained, this prospective, randomized, blinded clinical study was conducted in Sina hospital in Iran. Seventy-five patients who were scheduled for elective laparatomy surgery under isoflurane anesthesia were randomly allocated to receive either saline or 1 or 5 mg/kg of aminophylline (n = 25 for each) at the end of their anesthesia. The time to tracheal extubation and BIS after the administration of the study drug and the total time required until discharge from the post anesthesia care unit (PACU) were recorded.
Results: Seventy-five patients completed the study. Compared to saline, patients who received 1 and 5 mg/kg of aminophylline demonstrated decreased extubation times (mean±SD) (12.26±7.33 vs. 11.15±8.62 and 10.4±4.78 min, respectively, P = 0.001) with higher BIS values (P = 0.001). However, the recovery and discharge times from the PACU were no different between the aminophylline and saline groups.
Conclusions: The administration of high doses of aminophylline after laparatomy procedures with isoflurane anesthesia expedited the extubation time with no effects on discharge from the PACU.
Keywords
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