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Effect of medicinal syrup made from silkworm cocoon on mixed anxiety-depression disorder: A triple-blind randomized clinical trial

Document Type : Research articles

Authors

1 Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Psychiatry, Orumiyeh University of Medical Sciences, Orumiyeh, Iran

Abstract

OBJECTIVE: Silkworm cocoon produced by silkworms with the scientific name of Bombyx mori L. is a well-known medicinal agent mainly composed of proteins. This study was designed to assess the efficacy of syrup made from this natural agent on mild to moderate depression.
METHODS: The study was conducted based on a triple-blind randomized clinical trial. A total of 60 patients with mixed anxiety-depressive disorder were randomized to receive either intervention (silk syrup + sertraline) or control (placebo syrup + sertraline) for 12 weeks. Depression and anxiety were assessed using the Beck Depression and Anxiety inventories at weeks 0, 6, and 12.
RESULTS: Out of the subjects, 54 patients completed the trial in two groups of intervention (n=30) and control (n=24) and entered the final analysis. According to the results of this study, the mean of anxiety and depression scores in weeks 6 and week 12 was significantly lower in the intervention group than in the control group (P<0.001).
CONCLUSION: Silk syrup can be beneficial for the management of anxiety and depression in mild to moderate MADD; therefore, it is suggested as an adjuvant treatment to increase the efficacy of conventional medications adopted for the treatment of MADD patients.

Keywords

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Iranian Red Crescent Medical Journal (IRCMJ)
Volume 23, Issue 12 - Serial Number 12
2021
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History
  • Receive Date: 18 July 2021
  • Revise Date: 20 May 2024
  • Accept Date: 27 January 2024
  • First Publish Date: 27 January 2024
  • Publish Date: 01 December 2021
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