Document Type : Research articles

Authors

1 Department of Anesthesiology and Reanimation, Bak?rkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey

2 Department of Pediatric Nursing, Faculty of Health Sciences, Marmara University, Istanbul, Turkey

3 Department of Emergency Medicine, Bak?rkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey

Abstract

Background: Increasing in emergency department need to critical care, the number of intensive care unit bed worldwide is inad- equate to meet these applies.
Objectives: The aim of this study was to investigate the effect of waiting for admission to the Intensive Care Unit (ICU) in the Emer- gency Department (ED) on the length of stay in the ICU and the mortality of critically ill patients.
Methods: This retrospective cohort study carried out between January 2012 - 2019 patients admitted to the ICU of a training and research hospital. The data of 1297 adult patients were obtained by searching the Clinical Decision Support System.
Results: The data of the patients were evaluated in two groups as those considered to be delayed and non-delayed. It was determined that the delay of two hours increased the risk of mortality 1.5 times. Hazard Ratios (HR) was 1.548 (1.077 - 2.224). Patients whose ICU admission was delayed by 5 - 6 hours were found to have the highest risk in terms of mortality (HR = 2.291 [1.503 - 3.493]). A statistically significant difference was found in the ICU mortality, 28-day and, 90-day mortality between the two groups. ICU mortality for all patients general was 25.2% (327/1297). This rate was 11.4% (55/481) in the non-delayed group and 33.3% (272/816) in the delayed group (P < 0.001). The 28-day mortality rate for all patients general was 26.9% (349/1297). This rate was found to be 13.5% (65/481) in the non-delayed group and 34.8% (284/816) in the delayed group (P < 0.001). The 90-day mortality for all patients general was 28.4% (368/1297). This rate was 14.1% (68/481) in the non-delayed group and 36.8% (300/816) in the delayed group (P < 0.001).
Conclusions: Prolonged stay in the ED before admission to the ICU is associated with worse consequences, and increased mortality.
 

Keywords

  1. Khan BA, Shakeel N, Siddiqui EU, Kazi G, Khan IQ, Khursheed M, et al. Impact of delay in admission on the outcome of critically ill patients presenting to the emergency department of a tertiary care hospital from low income country. J Pak Med Assoc. 2016;66(5):509-16. [PubMed: 27183926].
  2. Doukhan L, Bisbal M, Chow-Chine L, Sannini A, Brun JP, Cambon S, et al. Respiratory events in ward are associated with later intensive care unit (ICU) admission and hospital mortality in onco-hematology patients not admitted to ICU after a first request. PLoS One. 2017;12(7). e0181808. doi: 10.1371/journal.pone.0181808. [PubMed: 28749989]. [PubMed Central: PMC5531489].
  3. Blow O, Magliore L, Claridge JA, Butler K, Young JS. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma. 1999;47(5):964-9. doi: 10.1097/00005373-199911000-00028. [PubMed: 10568731].
  4. Sebat F, Musthafa AA, Johnson D, Kramer AA, Shoffner D, Eliason M, et al. Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years. Crit Care Med. 2007;35(11):2568-75. doi: 10.1097/01.CCM.0000287593.54658.89. [PubMed: 17901831].
  5. Garcia-Gigorro R, de la Cruz Vigo F, Andres-Esteban EM, Chacon-Alves S, Morales Varas G, Sanchez-Izquierdo JA, et al. Impact on patient outcome of emergency department length of stay prior to ICU admission. Med Intensiva. 2017;41(4):201-8. doi: 10.1016/j.medin.2016.05.008. [PubMed: 27553889].
  6. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. Correction to: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e440-1. doi: 10.1161/STR.0000000000000215. [PubMed: 31765293].
  7. Lilly CM, Zuckerman IH, Badawi O, Riker RR. Benchmark data from more than 240,000 adults that reflect the current practice of critical care in the United States. Chest. 2011;140(5):1232-42. doi: 10.1378/chest.11-0718. [PubMed: 21868469].
  8. Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010;38(10):1947-53. doi: 10.1097/CCM.0b013e3181ef4460. [PubMed: 20639743].
  9. Herring AA, Ginde AA, Fahimi J, Alter HJ, Maselli JH, Espinola JA, et al. Increasing critical care admissions from U.S. emergency departments, 2001-2009. Crit Care Med. 2013;41(5):1197-204. doi: 10.1097/CCM.0b013e31827c086f. [PubMed: 23591207]. [PubMed Central: PMC3756824].
  10. McCaig LF, Burt CW. National Hospital Ambulatory Medical Care Survey: 2002 emergency department summary. Adv Data. 2004;(340):1-34. [PubMed: 15068333].
  11. Angus DC, Kelley MA, Schmitz RJ, White A, Popovich J Jr, Committee on Manpower for P, et al. Caring for the critically ill patient. Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease: can we meet the requirements of an aging population? JAMA. 2000;284(21):2762-70. doi: 10.1001/jama.284.21.2762. [PubMed: 11105183].
  12. Cardoso LT, Grion CM, Matsuo T, Anami EH, Kauss IA, Seko L, et al. Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study. Crit Care. 2011;15(1):R28. doi: 10.1186/cc9975. [PubMed: 21244671]. [PubMed Central: PMC3222064].
  13. Soni KD, Kaushik G, Gupta A, Singh V, Kumar S, Sagar S. From Emergency Department to Intensive Care Unit, Does The Delay Matter to Trauma Patients? J Emerg Trauma Shock. 2018;11(3):189-92. doi: 10.4103/JETS.JETS_132_17. [PubMed: 30429626]. [PubMed Central: PMC6182966].
  14. Fromm RE Jr, Gibbs LR, McCallum WG, Niziol C, Babcock JC, Gueler AC, et al. Critical care in the emergency department: a time-based study. Crit Care Med. 1993;21(7):970-6. doi: 10.1097/00003246-199307000-00009. [PubMed: 8319477].
  15. Al-Qahtani S, Alsultan A, Haddad S, Alsaawi A, Alshehri M, Alsolamy S, et al. The association of duration of boarding in the emergency room and the outcome of patients admitted to the intensive care unit. BMC Emerg Med. 2017;17(1):34. doi: 10.1186/s12873-017-0143-4. [PubMed: 29121883]. [PubMed Central: PMC5680599].
  16. Kadar RB, Amici DR, Hesse K, Bonder A, Ries M. Impact of Telemonitoring of Critically Ill Emergency Department Patients Awaiting ICU Transfer. Crit Care Med. 2019;47(9):1201-7. doi: 10.1097/CCM.0000000000003847. [PubMed: 31162198].
  17. Sprung CL, Geber D, Eidelman LA, Baras M, Pizov R, Nimrod A, et al. Evaluation of triage decisions for intensive care admission. Crit Care Med. 1999;27(6):1073-9. doi: 10.1097/00003246-199906000-00021. [PubMed: 10397207].
  18. Mathews KS, Durst MS, Vargas-Torres C, Olson AD, Mazumdar M, Richardson LD. Effect of Emergency Department and ICU Occupancy on Admission Decisions and Outcomes for Critically Ill Patients. Crit Care Med. 2018;46(5):720-7. doi: 10.1097/CCM.0000000000002993. [PubMed: 29384780]. [PubMed Central: PMC5899025].
  19. Robert R, Coudroy R, Ragot S, Lesieur O, Runge I, Souday V, et al. Influence of ICU-bed availability on ICU admission decisions. Ann Intensive Care. 2015;5(1):55. doi: 10.1186/s13613-015-0099-z. [PubMed: 26714805]. [PubMed Central: PMC4695477].
  20. Stelfox HT, Hemmelgarn BR, Bagshaw SM, Gao S, Doig CJ, Nijssen-Jordan C, et al. Intensive care unit bed availability and outcomes for hospitalized patients with sudden clinical deterioration. Arch Intern Med. 2012;172(6):467-74. doi: 10.1001/archinternmed.2011.2315. [PubMed: 22412076].
  21. Groenland CNL, Termorshuizen F, Rietdijk WJR, van den Brule J, Dongelmans DA, de Jonge E, et al. Emergency Department to ICU Time Is Associated With Hospital Mortality: A Registry Analysis of 14,788 Patients From Six University Hospitals in The Netherlands. Crit Care Med. 2019;47(11):1564-71. doi: 10.1097/CCM.0000000000003957. [PubMed: 31393321]. [PubMed Central: PMC6798749].
  22. Sagy I, Fuchs L, Mizrakli Y, Codish S, Politi L, Fink L, et al. Characteristics and outcomes of critically-ill medical patients admitted to a tertiary medical center with restricted ICU bed capacity. J Crit Care. 2018;43:281-7. doi: 10.1016/j.jcrc.2017.09.177. [PubMed: 28965037].
  23. Yarmohammadian MH, Rezaei F, Haghshenas A, Tavakoli N. Overcrowding in emergency departments: A review of strategies to decrease future challenges. J Res Med Sci. 2017;22:23. doi: 10.4103/1735-1995.200277. [PubMed: 28413420]. [PubMed Central: PMC5377968].
  24. Horwitz LI, Green J, Bradley EH. US emergency department performance on wait time and length of visit. Ann Emerg Med. 2010;55(2):133-41. doi: 10.1016/j.annemergmed.2009.07.023. [PubMed: 19796844]. [PubMed Central: PMC2830619].
  25. Trzeciak S, Rivers EP. Emergency department overcrowding in the United States: an emerging threat to patient safety and public health. Emerg Med J. 2003;20(5):402-5. doi: 10.1136/emj.20.5.402. [PubMed: 12954674]. [PubMed Central: PMC1726173].
  26. Derlet RW, Richards JR. Overcrowding in the nation's emergency departments: complex causes and disturbing effects. Ann Emerg Med. 2000;35(1):63-8. doi: 10.1016/s0196-0644(00)70105-3. [PubMed: 10613941].
  27. Peyrony O, Chevret S, Meert AP, Perez P, Kouatchet A, Pene F, et al. Direct admission to the intensive care unit from the emergency department and mortality in critically ill hematology patients. Ann Intensive Care. 2019;9(1):110. doi: 10.1186/s13613-019-0587-7. [PubMed: 31578641]. [PubMed Central: PMC6775178].
  28. Hsieh CC, Lee CC, Hsu HC, Shih HI, Lu CH, Lin CH. Impact of delayed admission to intensive care units on patients with acute respiratory failure. Am J Emerg Med. 2017;35(1):39-44. doi: 10.1016/j.ajem.2016.09.066. [PubMed: 27742520].
  29. Chalfin DB, Trzeciak S, Likourezos A, Baumann BM, Dellinger RP, Delay-Ed study group. Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med. 2007;35(6):1477-83. doi: 10.1097/01.CCM.0000266585.74905.5A. [PubMed: 17440421].
  30. Duke G, Green J, Briedis J. Survival of critically ill medical patients is time-critical. Crit Care Resusc. 2004;6(4):261-7. [PubMed: 16556104].
  31. Parkhe M, Myles PS, Leach DS, Maclean AV. Outcome of emergency department patients with delayed admission to an intensive care unit. Emerg Med (Fremantle). 2002;14(1):50-7. doi: 10.1046/j.1442-2026.2002.00286.x. [PubMed: 11993835].
  32. Simchen E, Sprung CL, Galai N, Zitser-Gurevich Y, Bar-Lavi Y, Gurman G, et al. Survival of critically ill patients hospitalized in and out of intensive care units under paucity of intensive care unit beds. Crit Care Med. 2004;32(8):1654-61. doi: 10.1097/01.ccm.0000133021.22188.35. [PubMed: 15286540].
  33. Group L. The results of the American Hospital Association survey of emergency department (ED) and hospital capacity. American Hosp Assoc; 2006.
  34. Young MP, Gooder VJ, McBride K, James B, Fisher ES. Inpatient transfers to the intensive care unit: delays are associated with increased mortality and morbidity. J Gen Intern Med. 2003;18(2):77-83. doi: 10.1046/j.1525-1497.2003.20441.x. [PubMed: 12542581]. [PubMed Central: PMC1494814].
  35. Carter AW, Pilcher D, Bailey M, Cameron P, Duke GJ, Cooper J. Is ED length of stay before ICU admission related to patient mortality? Emerg Med Australas. 2010;22(2):145-50. doi: 10.1111/j.1742-6723.2010.01272.x. [PubMed: 20534049].
  36. Haji K, Haji D, Tiruvoipati R, Bailey M, Le Blanc V, Botha JA. Impact of length of stay in emergency department on the outcome in patients with severe sepsis. Crit Care & Shock. 2010;13:132-7.
  37. Saukkonen KA, Varpula M, Rasanen P, Roine RP, Voipio-Pulkki LM, Pettila V. The effect of emergency department delay on outcome in critically ill medical patients: evaluation using hospital mortality and quality of life at 6 months. J Intern Med. 2006;260(6):586-91. doi: 10.1111/j.1365-2796.2006.01716.x. [PubMed: 17116010].
  38. Green RS, MacIntyre JK. Critical care in the emergency department: an assessment of the length of stay and invasive procedures performed on critically ill ED patients. Scand J Trauma Resusc Emerg Med. 2009;17:47. doi: 10.1186/1757-7241-17-47. [PubMed: 19778429]. [PubMed Central: PMC2761844].
  39. Thijssen W, Kraaijvanger N, Barten DG, Boerma MLM, Giesen P, Wensing M. Impact of a well-developed primary care system on the length of stay in emergency departments in the Netherlands: a multicenter study. BMC Health Serv Res. 2016;16:149. doi: 10.1186/s12913-016-1400-z. [PubMed: 27117479]. [PubMed Central: PMC4845371].
  40. Hung SC, Kung CT, Hung CW, Liu BM, Liu JW, Chew G, et al. Determining delayed admission to intensive care unit for mechanically ventilated patients in the emergency department. Crit Care. 2014;18(4):485. doi: 10.1186/s13054-014-0485-1. [PubMed: 25148726]. [PubMed Central: PMC4175615].
  41. Rincon F, Mayer SA, Rivolta J, Stillman J, Boden-Albala B, Elkind MS, et al. Impact of delayed transfer of critically ill stroke patients from the Emergency Department to the Neuro-ICU. Neurocrit Care. 2010;13(1):75-81. doi: 10.1007/s12028-010-9347-0. [PubMed: 20428969].
  42. Reznek MA, Murray E, Youngren MN, Durham NT, Michael SS. Door-to-Imaging Time for Acute Stroke Patients Is Adversely Affected by Emergency Department Crowding. Stroke. 2017;48(1):49-54. doi: 10.1161/STROKEAHA.116.015131. [PubMed: 27856953].
  43. Schull MJ, Vermeulen M, Slaughter G, Morrison L, Daly P. Emergency department crowding and thrombolysis delays in acute myocardial infarction. Ann Emerg Med. 2004;44(6):577-85. doi: 10.1016/j.annemergmed.2004.05.004. [PubMed: 15573032].
  44. Harris S, Singer M, Sanderson C, Grieve R, Harrison D, Rowan K. Impact on mortality of prompt admission to critical care for deteriorating ward patients: an instrumental variable analysis using critical care bed strain. Intensive Care Med. 2018;44(5):606-15. doi: 10.1007/s00134-018-5148-2. [PubMed: 29736785]. [PubMed Central: PMC6006241].
  45. Siletz A, Jin K, Cohen M, Lewis C, Tillou A, Cryer HM, et al. Emergency department length of stay in critical nonoperative trauma. J Surg Res. 2017;214:102-8. doi: 10.1016/j.jss.2017.02.079. [PubMed: 28624030].
  46. Lerner EB, Moscati RM. The golden hour: scientific fact or medical "urban legend"? Acad Emerg Med. 2001;8(7):758-60. doi: 10.1111/j.1553-2712.2001.tb00201.x. [PubMed: 11435197].
  47. Zhang Z, Bokhari F, Guo Y, Goyal H. Prolonged length of stay in the emergency department and increased risk of hospital mortality in patients with sepsis requiring ICU admission. Emerg Med