Prevention of Type 2 Diabetic Nephropathy

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Article Information:

Group: 2006
Subgroup: Volume 8, Issue 2
Date: September 2005
Type: Review Article
Start Page: 83
End Page: 91


  • M.R Ganji
  • ,
  • F Darvishzadeh
  • ,
  • I Najafi
  • ,
  • M.S Hakemi
  • ,
  • B Larijani
  • Department of Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran
    • Correspondence:

      Affiliation: Department of Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences
      City, Province: Tehran,
      Country: Iran
      Fax: 0098218029399


Diabetes Mellitus is a Major health problem in the most of word countries. In Northern America the population with type II diabetes will exceeds 300 millions in the next 25 years. In Iran, overall prevalence of diabetes mellitus is between 3.7% and 6% in rural and urban regions respectively. Prevalence of nephropathy among diabetic patients is 10% and 22.4% of all dialysis cases is related to diabetes. Protenuria necreases the cardiovascular death by 10 folds in subjects with type 1 diabetes. Similary in type 2 diabetes, microalbuminuria is a risk tactor for CHD by its association with both endothelial damage and nephropathy. Studies have suggested that prevention of the progression of diabetic nephropathy is associated with lower risk of cardiovascular death. Control of the modifiable risk factors such as blood glucose level, hyperlipidemia, hypertension, diet, smoking and proteinuria is necessary to prevent the disabilities and severe consequences of diabetes. This discussion is based on all available prospective studies to intervene contributing factors for prevention. It was tried to include EVIDENCE BASED MEDICINE grade A1 and A2 as explained separately. 


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